SCIENCE-JOBS-DE Stellenausschreibung (vacancies)
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Darwinian Chemistry Doctoral Network
Darwinian evolution is unrivalled in its ability to invent, which Humankind has already exploited for various purposes such as plant and animal breeding and directed evolution of proteins. In these examples, evolution acts on living species or material derived from them, but so far it has not been possible to apply Darwinian evolution outside the realm of biological and some computational systems. The aim of the DarChemDN research programme is to develop, for the first time, synthetic chemical systems that can undergo Darwinian evolution.
Host institution: ESPCI Paris, Laboratoire de Biochimie, Paris, France
The Laboratory of Biochemistry (LBC) is a multidisciplinary laboratory spanning physics, chemistry, and biology. The unifying theme of their research is the use of microfluidic systems, and in particular droplet microfluidic systems, to answer questions in the field of biology and for the development of biotechnology applications. Three main areas of fundamental research can be distinguished: (1) the emergence of Darwinian chemical systems (origin of life), (2)Darwinian system dynamics and directed evolution, and (3) single-cell analysis and screening. There is great synergy between fundamental research and applied projects, and this has resulted in the creation of several start-ups.
Project description: Study the autocatalytic formose reaction and its coupling to the growth and division of compartments (aqueous droplets in an emulsion) via osmosis and diffusion. Several crucial properties (growth, division, variation, competition, rudimentary heredity, and selection) are required for living and evolving systems to arise from this simple physical-chemical process. The aim here is to test whether the compartmentalised formose reaction system is capable of rudimentary evolution by natural selection. Specifically, DC3 will: (1) Develop microfluidic systems that allow multiple cycles of droplet growth and size-dependent droplet division. (2) Use this microfluidic system to monitor growth-division cycles of multiple “generations” of droplets, starting from mixtures of droplets with different initial compositions. (3) Aided by theoretical modelling, explore how initial conditions (temperature, sugars, food sets, or modulators such as amino acids or borates) may cause heritable variation in droplet growth rates. (4) Explore experimentally how evolution might be rendered more efficient by improving heredity and evolvability.
Eligibility conditions: Relevant MSc degree or equivalent (e.g., chemistry, biochemistry, physics).
Required Skills: The candidate should have expertise in fluid physics/physicochemistry and ideally microfluidics/microfabrication. They should have a strong command of written and spoken English.
Monthly allowances:
- Living allowance: €3400*
- Mobility allowance: €600
- Family allowance, if applicable: €660
Estimated gross salary: ~43,000 €/year
How to apply : send your CV and Cover Letter to "[log in to unmask]"
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Von:
Diab-Adams Freyfer
[log in to unmask]
ESPCI Paris
Paris, France
Ansprechpartner: Diab-Adams Freyfer, [log in to unmask]
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